The absolute anti-aging reference — the only cosmetic active whose stimulation of collagen is validated by decades of studies. Numbuzin and Medicube offer innovative formulations (retinal, liposomal encapsulation) that maximize efficacy while minimizing irritation.
01 · Type de peau
Mature, marked-wrinkle, spotted skin, acne-prone (with adapted formulas).
02 · Concentration efficace
0.1 to 1% for retinol; 0.05 to 0.3% for retinal.
03 · Compatibilité
Pairs well with: peptides, niacinamide, hyaluronic acid. Avoid with: strong AHA/BHA on the same evening, pure vitamin C (irritation).
Bénéfices mesurés
Ce que la science observe
Powerful stimulation of collagen synthesis
Fading of deep wrinkles
Refinement of skin texture
Brightening of dark spots
Sebum regulation
Secondary anti-acne effect
Mécanisme
Action moléculaire
Retinol is converted to retinoic acid by the skin via 2 enzymatic steps (retinol → retinal → retinoic acid). Retinoic acid binds to the nuclear RAR/RXR receptors and activates the transcription of collagen and keratinocyte differentiation genes.
Origine et tradition
Du palais aux laboratoires
Retinol was isolated in 1913. Its anti-aging cosmetic use began in the 1980s. Retinal (an intermediate with one fewer conversion step) has gained K-beauty popularity since 2020 for its better efficacy/tolerance ratio.
Protocole d'application
Mode d'emploi clinique
- Étape 01 Start 1 evening / week, then build up gradually
- Étape 02 Always in the evening, on dry skin, after cleansing
- Étape 03 SPF mandatory the next day
- Étape 04 Minimum 3-month cure for visible effect